采用酶放大免疫测定技术（EMIT）和毛细管气相色谱法对尿液中福尔可定进行代谢研究。

Metabolic study of pholcodine in urine using enzyme multiplied immunoassay technique (EMIT) and capillary gas chromatography.

作者信息

Johansen M, Rasmussen K E, Christophersen A S, Skuterud B

机构信息

Institute of Pharmacy, University of Oslo, Norway.

出版信息

Acta Pharm Nord. 1991;3(2):91-4.

PMID:1910552

Abstract

A study of pholcodine metabolism in man is reported. Three subjects received a single therapeutic oral dose of 50 mg pholcodine and urine samples were collected as long as a positive opiate response could be detected by EMIT (16-26 days). Pholcodine was found to conjugate with glucuronic acid and 15% (13-17%) of the pholcodine dose was excreted in urine as the glucuronide, and 29% (24-35%) as unconjugated pholcodine. Morphine was detected to be a metabolite of pholcodine and 0.5-1% of the pholcodine dose was excreted as morphine glucuronide. The identity of morphine was confirmed by capillary gas chromatography-mass spectroscopy (GC-MS).

摘要

本文报道了一项关于人身体中福可定代谢的研究。三名受试者口服了50毫克的单一治疗剂量福可定，只要能通过酶放大免疫测定技术（EMIT）检测到阳性阿片反应（持续16 - 26天），就收集尿液样本。研究发现福可定与葡萄糖醛酸结合，给药剂量的15%（13% - 17%）以葡萄糖醛酸苷的形式随尿液排出，29%（24% - 35%）以未结合的福可定形式排出。检测到吗啡是福可定的一种代谢产物，给药剂量的0.5% - 1%以吗啡葡萄糖醛酸苷的形式排出。吗啡的身份通过毛细管气相色谱 - 质谱联用仪（GC - MS）得以确认。