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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Dinsdale D, Williams R B

Br J Nutr. 1977 Jan;37(1):135-42. doi: 10.1079/bjn19770013.

The incidence of colchicine-induced lesions in the germinal epithelium oof the rat duodenum was studied in young rats in an early stage of zinc deficiency and in their pair-fed controls. At both dose levels of colchicine used, a marked increase in the amount of cell damage was observed in the duodenum of Zn-deficient rats as compared with the pair-fed, control (Zn-supplemented) rats. 2. No statistical interaction between Zn and colchicine was demonstrable, and no lesions were found in the duodenum of animals that had not been treated with colchicine. 3. The results are discussed in relation to the effects of Zn deficiency in animals and the possible involvement of Zn in the maintenance of the integrity of microtubular structures.

在缺锌幼鼠及其配对喂养的对照鼠中，研究了秋水仙碱诱导的大鼠十二指肠生发上皮损伤的发生率。在所使用的两个秋水仙碱剂量水平下，与配对喂养的对照（补锌）大鼠相比，缺锌大鼠十二指肠中的细胞损伤量显著增加。2. 锌和秋水仙碱之间未显示出统计学上的相互作用，且未用秋水仙碱处理的动物十二指肠中未发现病变。3. 结合锌缺乏对动物的影响以及锌可能参与维持微管结构完整性的情况对结果进行了讨论。

Dinsdale D, Williams R B

Br J Nutr. 1977 Jan;37(1):135-42. doi: 10.1079/bjn19770013.

The incidence of colchicine-induced lesions in the germinal epithelium oof the rat duodenum was studied in young rats in an early stage of zinc deficiency and in their pair-fed controls. At both dose levels of colchicine used, a marked increase in the amount of cell damage was observed in the duodenum of Zn-deficient rats as compared with the pair-fed, control (Zn-supplemented) rats. 2. No statistical interaction between Zn and colchicine was demonstrable, and no lesions were found in the duodenum of animals that had not been treated with colchicine. 3. The results are discussed in relation to the effects of Zn deficiency in animals and the possible involvement of Zn in the maintenance of the integrity of microtubular structures.

在缺锌幼鼠及其配对喂养的对照鼠中，研究了秋水仙碱诱导的大鼠十二指肠生发上皮损伤的发生率。在所使用的两个秋水仙碱剂量水平下，与配对喂养的对照（补锌）大鼠相比，缺锌大鼠十二指肠中的细胞损伤量显著增加。2. 锌和秋水仙碱之间未显示出统计学上的相互作用，且未用秋水仙碱处理的动物十二指肠中未发现病变。3. 结合锌缺乏对动物的影响以及锌可能参与维持微管结构完整性的情况对结果进行了讨论。