Leure-duPree A E, McClain C J
Invest Ophthalmol Vis Sci. 1982 Oct;23(4):425-34.
Male Sprague-Dawley weanling rats maintained on a controlled dietary zinc intake had an accumulation of osmiophilic inclusion bodies in the retinal pigment epithelium (RPE) of the zinc-deficient group. At 7 weeks of zinc deficiency there were marked ultrastructural alterations of the RPE. In some instances a deepening of the basal infoldings of the cells of the RPE were observed. There was also vesiculation and degeneration of the photoreceptor outer segments. No changes were observed in the pair-fed, weight-restricted, and ad libitum-fed controls. The possible functions of zinc in the retina are discussed.
以可控的锌摄入量进行饮食喂养的雄性斯普拉格-道利断奶大鼠，缺锌组的视网膜色素上皮（RPE）中出现了嗜锇性包涵体的积累。缺锌7周时，RPE出现了明显的超微结构改变。在某些情况下，观察到RPE细胞基底褶皱加深。光感受器外段也出现了小泡形成和变性。在配对喂养、体重受限和自由进食的对照组中未观察到变化。文中讨论了锌在视网膜中的可能功能。
