无需保护基团的全合成：吡咯烷和环状氨基甲酸酯。
Total synthesis without protecting groups: pyrrolidines and cyclic carbamates.
作者信息
Dangerfield Emma M, Timmer Mattie S M, Stocker Bridget L
机构信息
Malaghan Institute of Medical Research, PO Box 7060, Wellington, New Zealand.
出版信息
Org Lett. 2009 Feb 5;11(3):535-8. doi: 10.1021/ol802484y.
PMID:19105656
Abstract
A protecting group free synthesis of 2,3-cis substituted hydroxypyrrolidines is reported. Two novel reaction methodologies allow for the stereoselective formation of cyclic carbamates from olefinic amines, and the formation of primary amines via a Vasella/reductive amination reaction, both performed in aqueous media.
摘要
报道了一种无保护基团合成2,3-顺式取代羟基吡咯烷的方法。两种新颖的反应方法能够在水性介质中，从烯胺立体选择性地形成环状氨基甲酸酯，并通过瓦塞拉/还原胺化反应形成伯胺。
Zotero 插件