反选择性烯烃二胺化高效合成手性 2,2'-联吡啶
Efficient synthesis of chiral 2,2'-bipyrrolidines by an anti-selective alkene diamination.
机构信息
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Corrensstrasse 40, 48149 Münster, Germany.
出版信息
Org Lett. 2012 Dec 7;14(23):5944-7. doi: 10.1021/ol302855z. Epub 2012 Nov 26.
PMID:23181768
Abstract
The rapid and efficient construction of complex chiral bicyclic amines is possible using a novel alkene diamination reaction. Electrophilic iodinating agents promote the intramolecular anti-selective diamination of alkenes and allow the efficient synthesis of chiral amines such as trans-bipyrrolidines.
摘要
使用新型烯烃双氨化反应，可以快速有效地构建复杂的手性双环胺。亲电碘化试剂促进烯烃的分子内反选择性双氨化，从而能够高效合成手性胺，如反式双吡咯烷。
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