Olton D S, Markowska A, Breckler S J, Wenk G L, Pang K C, Koliatsos V
Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218.
Biomed Environ Sci. 1991 Jun;4(1-2):166-72.
Aged populations have remarkable variability in recent memory and cognitive mapping. Although some individuals may have substantial age-related impairments, others perform almost as well as young individuals. This paper reviews the relevant data on aged rats and indicates two challenges for biomarkers of aging. The first is to provide an appropriate quantitative description of these individual differences. The second is to use them effectively as markers for age-related changes in psychological functions and their neural substrates.
老年人群在近期记忆和认知图谱方面存在显著差异。尽管一些个体可能有明显的与年龄相关的损伤，但另一些个体的表现几乎与年轻人一样好。本文回顾了有关老年大鼠的相关数据，并指出了衰老生物标志物面临的两个挑战。第一个挑战是对这些个体差异提供适当的定量描述。第二个挑战是有效地将它们用作心理功能及其神经基质中与年龄相关变化的标志物。
