Ishibashi Keiichiro, Yokoyama Masaru, Okada Norimichi, Ishiguro Toru, Ohsawa Tomonori, Mitsuhashi Toshitake, Miyazaki Tatsuya, Matsuki Moriyuki, Ishida Hideyuki, Fukuda Hiroki, Gika Masatoshi, Yamahata Takeshi, Eguchi Keisuke, Nakayama Mitsuo, Kikuchi Kouji
Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
Gan To Kagaku Ryoho. 2008 Nov;35(12):2186-8.
This retrospective study evaluated the prognosis of patients undergoing resection of both hepatic and pulmonary metastases from colorectal cancer. The subjects were 14 patients who underwent resection of both hepatic and pulmonary metastases from colorectal cancer between January 1991 and January 2008. The range of patient age at first metastatectomy was 48- 73-years-old (median 59). The ratio of males to females was 4 to 3. Hepatic metastatectomy proceeded to pulmonary metastatectomy in 10 cases, while pulmonary metastatectomy was performed first in 4 cases. The median duration of relapse-free survival and overall survival after the second metastatectomy was 11.2 months and 20.4 months, respectively. The overall survival after the second metastatectomy tended to correlate with the relapse-free survival after the first metastatectomy (rs=0.55, p=0.08). In conclusion, relapse-free survival after the first metastatectomy should be considered when a second metastatectomy is scheduled in patients with both hepatic and pulmonary metastases from colorectal cancer.
这项回顾性研究评估了接受结直肠癌肝转移和肺转移切除术患者的预后。研究对象为1991年1月至2008年1月期间接受结直肠癌肝转移和肺转移切除术的14例患者。首次转移灶切除时患者年龄范围为48 - 73岁（中位年龄59岁）。男女比例为4比3。10例患者先进行肝转移灶切除，然后进行肺转移灶切除，4例患者先进行肺转移灶切除。第二次转移灶切除术后无复发生存期和总生存期的中位数分别为11.2个月和20.4个月。第二次转移灶切除术后的总生存期与首次转移灶切除术后的无复发生存期呈正相关趋势（rs = 0.55，p = 0.08）。总之，对于计划进行第二次转移灶切除术的结直肠癌肝转移和肺转移患者，应考虑首次转移灶切除术后的无复发生存期。
