Kimura Osamu, Kuroda Hirohiko, Iwamoto Akemi, Yamane Nariyuki, Hamazoe Ryuichi
Dept. of Surgery, National Hospital Organization Yonago Medical Center.
Gan To Kagaku Ryoho. 2008 Nov;35(12):2189-91.
We analyzed the results of hepatic arterial infusion chemotherapy (HAIC) for 21 patients with synchronous liver metastases from colorectal cancer for the last ten years to investigate the usefulness of HAIC for those patients. In 7 cases with resection of liver metastases, the median survival time (MST) was 49 months, mean survival time was 56.3 months and a 5-year survival rate was 43%. In 14 cases without resection of liver metastases, 2 cases had complete response (CR), 8 cases had partial response (PR), 4 cases had stable disease (SD), and the response rate was 71%. There was a significant difference in the survival time of each response. MST was 27 months, and mean survival time was 38.5 months. According to the usefulness of HAIC for the patients with synchronous liver metastases from colorectal cancer, it seems that HAIC with effective general chemotherapy will have better results than HAIC.
我们分析了过去十年中21例结直肠癌同时性肝转移患者的肝动脉灌注化疗（HAIC）结果，以研究HAIC对这些患者的有效性。在7例肝转移灶切除的病例中，中位生存时间（MST）为49个月，平均生存时间为56.3个月，5年生存率为43%。在14例未切除肝转移灶的病例中，2例完全缓解（CR），8例部分缓解（PR），4例疾病稳定（SD），缓解率为71%。各缓解情况的生存时间存在显著差异。MST为27个月，平均生存时间为38.5个月。根据HAIC对结直肠癌同时性肝转移患者的有效性，似乎有效的全身化疗联合HAIC将比单纯HAIC产生更好的结果。
