Benacerraf B
Department of Pathology, Harvard Medical School, Boston, Massachusetts.
Annu Rev Immunol. 1991;9:1-26. doi: 10.1146/annurev.iy.09.040191.000245.
Dr. Benacerraf describes his experience in training immunologists for a period of over 30 years. He then analyzes the circumstances in which selected discoveries were made in his laboratory and the events and reasoning that led to these findings. The following topics are discussed: The phagocytic activity of the reticulo-endothelial system. The pathogenesis of immune complex diseases. The impact of activated macrophages on tumor rejection. The evidence that T-cell immunity is specific for internal protein determinants generated by antigen processing. The maturation of the antibody response in terms of antibody affinity. The discovery of Ir gene control of specific immune responses and the role of MHC molecules as presenters of peptide antigens to T cells. The generation of alloreactivity. Lastly, he addresses the administration of science and, particularly, the problems related to the transfer of technology to industrial partners.
贝纳塞拉夫博士描述了他30多年来培训免疫学家的经历。然后，他分析了在他的实验室中做出某些特定发现时的情况，以及导致这些发现的事件和推理过程。讨论了以下主题：网状内皮系统的吞噬活性。免疫复合物疾病的发病机制。活化巨噬细胞对肿瘤排斥的影响。T细胞免疫针对由抗原加工产生的内部蛋白质决定簇具有特异性的证据。抗体亲和力方面抗体反应的成熟。Ir基因对特异性免疫反应的控制的发现以及MHC分子作为肽抗原呈递给T细胞的作用。同种异体反应性的产生。最后，他谈到了科学管理，特别是与向工业伙伴转让技术相关的问题。
