Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, 95817, United States.
Cell Immunol. 2012;273(2):99-108. doi: 10.1016/j.cellimm.2011.12.009. Epub 2012 Jan 3.
During his long career as a principal investigator and educator, Eli Sercarz trained over 100 scientists. He is best known for developing hen egg white lysozyme (HEL) as a model antigen for immunologic studies. Working in his model system Eli furthered our understanding of antigen processing and immunologic tolerance. His work established important concepts of how the immune system recognizes antigenic determinants processed from whole protein antigens; specifically he developed the concepts of immunodominance and crypticity. Later in his career he focused more on autoimmunity using a variety of established animal models to develop theories on how T cells can circumvent tolerance induction and how an autoreactive immune response can evolve over time. His theory of "determinant spreading" is one of the cornerstones of our modern understanding of autoimmunity. This review covers Eli's entire scientific career outlining his many seminal discoveries.
在他作为首席研究员和教育家的漫长职业生涯中，Eli Sercarz 培养了 100 多名科学家。他以开发蛋清溶菌酶（HEL）作为免疫研究的模型抗原而闻名。在他的模型系统中，Eli 进一步加深了我们对抗原加工和免疫耐受的理解。他的工作确立了免疫系统如何识别从完整蛋白质抗原中加工的抗原决定簇的重要概念；具体来说，他提出了免疫显性和隐匿性的概念。在职业生涯的后期，他使用各种已建立的动物模型更专注于自身免疫，以发展关于 T 细胞如何规避耐受诱导以及自身反应性免疫反应如何随时间演变的理论。他的“决定簇扩展”理论是我们现代自身免疫理解的基石之一。这篇综述涵盖了 Eli 的整个科学生涯，概述了他的许多开创性发现。
