McCune J, Kaneshima H, Krowka J, Namikawa R, Outzen H, Peault B, Rabin L, Shih C C, Yee E, Lieberman M
SyStemix, Inc., Palo Alto, California 94303.
Annu Rev Immunol. 1991;9:399-429. doi: 10.1146/annurev.iy.09.040191.002151.
The SCID-hu mouse is a heterochimeric small animal model designed to support hematopoietic differentiation and function in vivo. Multiple organs of the human hematolymphoid system have been successfully engrafted into the immunodeficient C.B-17 scid scid mouse, including fetal liver, thymus, lymph node, and skin. Co-implantation of human fetal liver and human fetal thymus results in long-term, multilineage human hematopoiesis in vivo. Mature human lymphocytes within the SCID-hu mouse are phenotypically and functionally normal. HIV infection of the SCID-hu mouse reflects a tropism similar to that found in humans: only human organs with CD4+ cells are infected. Viral replication can thereafter be monitored with assays that are safe, reproducible, and quantitative. Given this small animal model, it is now possible to study systematically the infective process of HIV and to address questions about the efficacy of novel antiviral compounds or vaccines in vivo.
重症联合免疫缺陷-人源化小鼠（SCID-hu小鼠）是一种异种嵌合小动物模型，旨在支持体内造血细胞的分化和功能。人类血液淋巴系统的多个器官已成功移植到免疫缺陷的C.B-17 scid scid小鼠体内，包括胎儿肝脏、胸腺、淋巴结和皮肤。人胎儿肝脏与人胎儿胸腺的共同植入可导致体内长期、多谱系的人类造血。SCID-hu小鼠体内的成熟人类淋巴细胞在表型和功能上均正常。SCID-hu小鼠的HIV感染反映出一种与人类相似的嗜性：只有带有CD4+细胞的人类器官会被感染。此后，可以通过安全、可重复且定量的检测方法监测病毒复制。鉴于这种小动物模型，现在有可能系统地研究HIV的感染过程，并解决有关新型抗病毒化合物或疫苗在体内疗效的问题。
