Marchand D, Tayara N, Choukroun M-L, Sarrat A, Guenard H, Demarquez J-L, Tunon De Lara J-M, Fayon M
Hôpital Pellegrin-Enfants, Pneumologie Pédiatrique et Centre de Recherche (CEDRE), CHU de Bordeaux, France.
Rev Mal Respir. 2008 Nov;25(9):1087-93. doi: 10.1016/s0761-8425(08)74978-7.
Exhaled nitric oxide (FeNO) is a putative non-invasive marker of eosinophilic airway inflammation with a good predictive value for allergic asthma in preschool children. The aim of the present study was to compare FeNO after acute viral bronchiolitis (AVB) in children aged less than 2 years without atopic dermatitis (AD) vs those with atopic dermatitis, as well as children with AD without any history of AVB.
Forty-two children (mean age +/- SD: 12.3 +/- 5.2 months; range 5.0-23.5; sex-ratio M: F=1.3: 1) were included in this prospective study, > 8 wks after an episode of AVB. The patients' atopic status was assessed both by clinical phenotype and IgE- mediated response to inhaled and/or food allergens. FeNO (ppb) was measured off-line by the chemoluminescence method on samples obtained from gas collected in a balloon during tidal breathing.
There was a significant difference between the AVB/AD (23.4 +/- 14.3 ppb, n=15) vs the AVB without AD group (13.5 +/- 10. 1 ppb, n=13) or the AD without AVB group (11.0 +/- 8.3 ppb, n=14). Maternal feeding for more than 2 months decreased FeNO by 50%.
Atopic children below 2 years with AD produce more NO after AVB than non-atopic children or atopic children without any history of AVB. Maternal feeding decreases FeNO.
呼出一氧化氮（FeNO）是嗜酸性气道炎症的一种假定非侵入性标志物，对学龄前儿童过敏性哮喘具有良好的预测价值。本研究的目的是比较2岁以下无特应性皮炎（AD）的急性病毒性细支气管炎（AVB）患儿与患有特应性皮炎的患儿，以及无AVB病史的AD患儿的FeNO水平。
本前瞻性研究纳入了42名儿童（平均年龄±标准差：12.3±5.2个月；范围5.0 - 23.5；性别比男：女 = 1.3：1），在AVB发作8周后进行研究。通过临床表型和对吸入和/或食物过敏原的IgE介导反应评估患者的特应性状态。通过化学发光法离线测量在潮气呼吸期间从气球收集的气体样本中的FeNO（ppb）。
AVB/AD组（23.4±14.3 ppb，n = 15）与无AD的AVB组（13.5±10.1 ppb，n = 13）或无AVB的AD组（11.0±8.3 ppb，n = 14）之间存在显著差异。母乳喂养超过2个月可使FeNO降低50%。
2岁以下患有AD的特应性儿童在AVB后产生的NO比非特应性儿童或无AVB病史的特应性儿童更多。母乳喂养会降低FeNO。
