Ingulli Elizabeth, Funatake Castle, Jacovetty Erica L, Zanetti Maurizio
Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
J Immunol. 2009 Jan 1;182(1):29-33. doi: 10.4049/jimmunol.182.1.29.
Influenza A virus infection induces massive inflammation and lung damage. Activation of CD8 T cells by dendritic cells (DCs) is necessary to control disease. We undertook studies to track directly Ag presentation to CD8 T cells in vivo through the first 72 h after infection with OVA-expressing influenza A virus. We found that Ag presentation by DCs occurs strictly in the draining lymph nodes and not within the lung itself. Surprisingly, Ag presentation was found to be mediated by a CD11b(+) DC population. Finally, the expression of antigenic complexes on DCs correlated with the location and timing of CD8 T cell activation. These results have implications for approaches to control influenza A virus infection.
甲型流感病毒感染会引发大规模炎症和肺部损伤。树突状细胞（DCs）激活CD8 T细胞对于控制疾病至关重要。我们开展了研究，以直接追踪在感染表达OVA的甲型流感病毒后的最初72小时内体内抗原呈递给CD8 T细胞的情况。我们发现，DCs的抗原呈递严格发生在引流淋巴结中，而非肺本身。令人惊讶的是，发现抗原呈递是由CD11b(+) DC群体介导的。最后，DCs上抗原复合物的表达与CD8 T细胞激活的位置和时间相关。这些结果对控制甲型流感病毒感染的方法具有启示意义。
