太阳来了：对紫外线损伤DNA的识别。
Here comes the sun: recognition of UV-damaged DNA.
作者信息
Chu Gilbert, Yang Wei
机构信息
Departments of Medicine and Biochemistry, CCSR1145, Division of Oncology, Stanford University Medical Center, Stanford, CA 94305-5151, USA.
出版信息
Cell. 2008 Dec 26;135(7):1172-4. doi: 10.1016/j.cell.2008.12.015.
Abstract
The first step in the repair of DNA damage is lesion detection. In this issue, Scrima et al. (2008) report the structure of the complex of DNA Damage-Binding Protein 1 (DDB1) and DDB2 bound to a DNA photodimer, providing critical insight into the repair of DNA damage caused by ultraviolet light.
摘要
DNA损伤修复的第一步是损伤检测。在本期中，斯克里马等人（2008年）报道了与DNA光二聚体结合的DNA损伤结合蛋白1（DDB1）和DDB2复合物的结构，为深入了解紫外线引起的DNA损伤修复提供了关键线索。
相似文献
1
Here comes the sun: recognition of UV-damaged DNA.
Cell. 2008 Dec 26;135(7):1172-4. doi: 10.1016/j.cell.2008.12.015.
2
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Cell. 2008 Dec 26;135(7):1213-23. doi: 10.1016/j.cell.2008.10.045.
3
Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein.
DNA Repair (Amst). 2002 Aug 6;1(8):601-16. doi: 10.1016/s1568-7864(02)00052-6.
4
DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.
J Biol Chem. 2005 Dec 2;280(48):39982-9. doi: 10.1074/jbc.M507854200. Epub 2005 Aug 24.
5
Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates.
Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1862-71. doi: 10.1073/pnas.1323856111. Epub 2014 Apr 23.
6
An ultraviolet light-damaged DNA recognition protein absent in xeroderma pigmentosum group E cells binds selectively to pyrimidine (6-4) pyrimidone photoproducts.
Nucleic Acids Res. 1992 Nov 11;20(21):5805-10. doi: 10.1093/nar/20.21.5805.
7
A newly identified patient with clinical xeroderma pigmentosum phenotype has a non-sense mutation in the DDB2 gene and incomplete repair in (6-4) photoproducts.
J Invest Dermatol. 1999 Aug;113(2):251-7. doi: 10.1046/j.1523-1747.1999.00652.x.
8
Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.
J Biol Chem. 2012 Apr 6;287(15):12036-49. doi: 10.1074/jbc.M111.307058. Epub 2012 Feb 10.
9
Repair of UV-endonuclease-susceptible sites in the 7 complementation groups of xeroderma pigmentosum A through G.
Mutat Res. 1979 Sep;62(2):363-8. doi: 10.1016/0027-5107(79)90091-5.
10
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2588-93. doi: 10.1073/pnas.0511160103. Epub 2006 Feb 10.
引用本文的文献
1
Interaction of DDB1 with NBS1 in a DNA Damage Checkpoint Pathway.
Int J Mol Sci. 2024 Dec 5;25(23):13097. doi: 10.3390/ijms252313097.
2
Hepatocyte-specific loss of DDB1 attenuates hepatic steatosis but aggravates liver inflammation and fibrosis in MASH.
Hepatol Commun. 2024 Jun 27;8(7). doi: 10.1097/HC9.0000000000000474. eCollection 2024 Jul 1.
3
The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.
Cell Cycle. 2012 Dec 1;11(23):4378-84. doi: 10.4161/cc.22688. Epub 2012 Nov 16.
4
Multiple skin cancers in adults with mutations in the XP-E (DDB2) DNA repair gene.
J Invest Dermatol. 2011 Mar;131(3):785-8. doi: 10.1038/jid.2010.352. Epub 2010 Nov 25.
5
DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.
Mol Cell Biol. 2010 Jun;30(11):2708-23. doi: 10.1128/MCB.01460-09. Epub 2010 Apr 5.
本文引用的文献
1
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Cell. 2008 Dec 26;135(7):1213-23. doi: 10.1016/j.cell.2008.10.045.
2
Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA.
EMBO Rep. 2008 Oct;9(10):1034-40. doi: 10.1038/embor.2008.155. Epub 2008 Aug 15.
3
Structure and mechanism for DNA lesion recognition.
Cell Res. 2008 Jan;18(1):184-97. doi: 10.1038/cr.2007.116.
4
Recognition of DNA damage by the Rad4 nucleotide excision repair protein.
Nature. 2007 Oct 4;449(7162):570-5. doi: 10.1038/nature06155. Epub 2007 Sep 19.
5
RETRACTED: Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo.
Mol Cell. 2006 Aug;23(4):471-82. doi: 10.1016/j.molcel.2006.06.029.
6
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.
Cell. 2005 May 6;121(3):387-400. doi: 10.1016/j.cell.2005.02.035.
7
Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair.
Science. 2004 Dec 3;306(5702):1789-93. doi: 10.1126/science.1101598.
8
Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein.
DNA Repair (Amst). 2002 Aug 6;1(8):601-16. doi: 10.1016/s1568-7864(02)00052-6.
9
p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.
Mol Cell Biol. 2002 May;22(10):3247-54. doi: 10.1128/MCB.22.10.3247-3254.2002.
10
Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: structural basis for damaged DNA recognition.
Cell. 1995 Dec 1;83(5):773-82. doi: 10.1016/0092-8674(95)90190-6.
Zotero 插件