Klement W, Arndt J O
Abteilung für Experimentelle Anaesthesiologie, Heinrich-Heine-Universität, Düsseldorf, Germany.
Br J Anaesth. 1991 Sep;67(3):281-4. doi: 10.1093/bja/67.3.281.
The emulsion formulation of propofol (Diprivan) evokes pain on i.v. injection, although its pH and osmolality are close to those of blood. The pain induced by serial dilutions of propofol in Intralipid and 5% glucose was examined in isolated vein segments and after intracutaneous injection. Propofol evoked pain in a concentration-related manner in six of eight subjects after i.v. perfusion and in all eight subjects after intracutaneous injections. Pain was maximal with propofol 56 x 10(-3) mol litre-1 when visual analogue pain scale was 60% of maximum (range 20-92%) for venous perfusion and 89% (range 66-100%) for intracutaneous injection. Dilution with 10% Intralipid reduced pain more than that with 5% glucose. We conclude that the intensity of pain after i.v. injection of propofol was related to its free aqueous concentration.
丙泊酚（得普利麻）的乳剂配方在静脉注射时会引起疼痛，尽管其pH值和渗透压与血液相近。在离体静脉段和皮内注射后，研究了丙泊酚在脂质乳剂和5%葡萄糖中连续稀释所引起的疼痛。静脉灌注后，8名受试者中有6名，皮内注射后8名受试者全部出现丙泊酚以浓度相关的方式引起疼痛。当视觉模拟疼痛量表为最大值的60%（静脉灌注范围为20 - 92%，皮内注射为89%（范围为66 - 100%））时，丙泊酚浓度为56×10⁻³摩尔/升时疼痛最为剧烈。用10%脂质乳剂稀释比用5%葡萄糖更能减轻疼痛。我们得出结论，静脉注射丙泊酚后的疼痛强度与其游离水相浓度有关。
