Bolshakova G B
Laboratory of Growth and Development, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2008 Apr;145(4):487-9. doi: 10.1007/s10517-008-0125-3.
Heart injury was inflicted to outbred albino rat fetuses on day 16 of prenatal development and cardiomyocyte proliferation was evaluated in the left ventricular zones adjacent to the wound and distant from it. The mitotic index of experimental animals was higher than in intact controls only for zones distant from the injury on day 10 after the intervention. The percentage of pathological metaphases gradually increased in all experimental groups, which causes doubt in the viability of postmitotic cardiomyocytes.
在产前发育的第16天，对远交系白化大鼠胎儿造成心脏损伤，并评估伤口附近和远离伤口的左心室区域的心肌细胞增殖情况。仅在干预后第10天，实验动物远离损伤区域的有丝分裂指数高于完整对照组。所有实验组中病理性中期的百分比逐渐增加，这使人对有丝分裂后心肌细胞的活力产生怀疑。
