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本文引用的文献

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Cardiac regeneration strategies: Staying young at heart.心脏再生策略：保持心脏年轻。
Science. 2017 Jun 9;356(6342):1035-1039. doi: 10.1126/science.aam5894. Epub 2017 Jun 8.
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Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation.肌营养不良蛋白-糖蛋白复合物隔离Yes相关蛋白以抑制心肌细胞增殖。
Nature. 2017 Jul 13;547(7662):227-231. doi: 10.1038/nature22979. Epub 2017 Jun 5.
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The extracellular matrix protein agrin promotes heart regeneration in mice.细胞外基质蛋白聚集蛋白聚糖可促进小鼠心脏再生。
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Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair.成体 c-kit（阳性）心脏干细胞对于功能性心脏再生和修复是必需且充分的。
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Science. 2011 Feb 25;331(6020):1078-80. doi: 10.1126/science.1200708.
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Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes.Gata4(+) 心肌细胞对斑马鱼心脏再生的主要贡献。
Nature. 2010 Mar 25;464(7288):601-5. doi: 10.1038/nature08804.
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心肌细胞增殖：松开刹车，踩下油门。

Cardiomyocyte proliferation: remove brakes and push accelerators.

作者信息

He Lingjuan, Zhou Bin

机构信息

The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

出版信息

Cell Res. 2017 Aug;27(8):959-960. doi: 10.1038/cr.2017.91. Epub 2017 Jul 14.

DOI:10.1038/cr.2017.91
PMID:28707671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5539355/
Abstract

Adult mammalian hearts cannot repair by themselves after injury due to limited proliferation of cardiomyocytes; removal of cell cycle blocker and/or addition of drugs that boost proliferation of cardiomyocytes provide potential means to cardiac regeneration. Three publications that appeared recently in Nature and Cell Research now provide new hope to the treatment of heart injuries.

摘要

成年哺乳动物的心脏在受伤后无法自行修复，因为心肌细胞的增殖能力有限；去除细胞周期阻滞剂和/或添加促进心肌细胞增殖的药物为心脏再生提供了潜在方法。最近发表在《自然》和《细胞研究》上的三篇论文为心脏损伤的治疗带来了新希望。