Singhal A, Kumar V L
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
J Ethnopharmacol. 2009 Feb 25;122(1):172-4. doi: 10.1016/j.jep.2008.12.002. Epub 2008 Dec 7.
The present study was carried out to evaluate the effect of dry latex (DL) of Calotropis procera, a plant of the family Asclepiadaceae, on the functions of liver and kidney in normal rats.
Aqueous suspension of DL was orally administered to rats at doses of 10, 100 and 400 mg/kg for a period of 45 days and the effect on various parameters reflecting liver and kidney functions was compared with that of normal controls.
Treatment with DL did not alter the serum levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), creatinine, urea and urinary levels of glucose and protein as compared to the normal rats. It exhibited a modulatory role in maintaining the levels of blood glucose and serum insulin. The liver and kidney of DL treated and normal rats were also comparable with regard to the tissue levels of oxidative stress markers and histology. Further, no signs of toxicity were observed in the DL treated rats over the study period.
Our study reveals that aqueous suspension of Calotropis procera latex does not produce any toxicity and could be safely used for therapeutic purpose at the doses studied.
本研究旨在评估萝藦科植物牛角瓜的干燥乳胶（DL）对正常大鼠肝脏和肾脏功能的影响。
将DL的水悬浮液以10、100和400mg/kg的剂量口服给予大鼠，持续45天，并将其对反映肝脏和肾脏功能的各种参数的影响与正常对照组进行比较。
与正常大鼠相比，用DL处理未改变血清天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）、肌酐、尿素以及尿液中葡萄糖和蛋白质的水平。它在维持血糖和血清胰岛素水平方面发挥调节作用。在氧化应激标志物的组织水平和组织学方面，经DL处理的大鼠和正常大鼠的肝脏和肾脏也具有可比性。此外，在研究期间，经DL处理的大鼠未观察到任何毒性迹象。
我们的研究表明，牛角瓜乳胶的水悬浮液不会产生任何毒性，在所研究的剂量下可安全用于治疗目的。
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