O'Hanlon Simon J, Enright Mark C
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Old Medical School Building, St Mary's Hospital, Norfolk Place, London W2 1PG, UK.
Int J Antimicrob Agents. 2009 May;33(5):427-31. doi: 10.1016/j.ijantimicag.2008.10.020. Epub 2008 Dec 27.
We evaluated the antistaphylococcal activity of Cliniweave (CW), a commercially available textile treatment designed for use in healthcare environments. In tests on genetically diverse isolates of Staphylococcus aureus, including 49 meticillin-resistant S. aureus (MRSA), the median minimum inhibitory concentration of the liquid compound was found to be 1 microg/L (range 0.5-2 microg/L). Comparison of the antimicrobial activity of CW-treated polyester with three other commercially available silver-based antimicrobial fabrics showed that after exposure of cultures of ca. 10(6) colony-forming units/mL of S. aureus, only CW-treated fabric showed any significant antibacterial activity, severely reducing bacterial numbers within 1h. Time-kill analysis of liquid CW in culture showed 2 log and 3 log reductions of S. aureus numbers within 30 min and 240 min, respectively, and 2 log reductions were observed within 60 min using treated fabric. CW-treated fabrics are strongly biocidal and may be useful in helping reduce the burden of nosocomial bacterial infection.
我们评估了Cliniweave（CW）的抗葡萄球菌活性，CW是一种专为医疗环境设计的商用纺织品处理剂。在对包括49株耐甲氧西林金黄色葡萄球菌（MRSA）在内的基因多样的金黄色葡萄球菌分离株进行的测试中，发现该液体化合物的最低抑菌浓度中位数为1微克/升（范围为0.5 - 2微克/升）。将经CW处理的聚酯与其他三种商用银基抗菌织物的抗菌活性进行比较，结果显示，在接种约10⁶菌落形成单位/毫升金黄色葡萄球菌的培养物后，只有经CW处理的织物表现出显著的抗菌活性，在1小时内可大幅减少细菌数量。对培养物中的液体CW进行的时间 - 杀菌分析表明，金黄色葡萄球菌数量在30分钟和240分钟内分别减少了2个对数级和3个对数级，使用经处理的织物在60分钟内观察到减少了2个对数级。经CW处理的织物具有很强的杀菌作用，可能有助于减轻医院细菌感染的负担。
