Moseley J M, Danks J A, Grill V, Lister T A, Horton M A
St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
Br J Cancer. 1991 Oct;64(4):745-8. doi: 10.1038/bjc.1991.391.
The infiltrated tissues from seven West Indian patients with HTLV-1 positive adult T cell lymphoma/leukaemia (ATLL) have been analysed by immunocytochemical techniques for the presence of immunoreactive parathyroid hormone-related protein (PTHrP), a hormonal mediator of humoral hypercalcaemia of malignancy. Six of the seven were hypercalcaemic at some stage of the course of their disease. Four of the six evaluable patients showed evidence of specific cellular and extracellular expression of PTHrP protein in neoplastic tissues. This finding suggests that PTHrP may be involved in the production of hypercalcaemia in at least some cases of T cell lymphoma - proof of a causal relationship however must await the demonstration of tissue release of PTHrP resulting in raised circulating hormone levels.
对7例西印度群岛HTLV - 1阳性成人T细胞淋巴瘤/白血病（ATLL）患者的浸润组织进行了免疫细胞化学技术分析，以检测免疫反应性甲状旁腺激素相关蛋白（PTHrP）的存在，PTHrP是恶性肿瘤体液性高钙血症的一种激素介质。7例患者中有6例在病程的某个阶段出现高钙血症。6例可评估患者中有4例在肿瘤组织中显示出PTHrP蛋白特异性细胞和细胞外表达的证据。这一发现表明，PTHrP可能至少在某些T细胞淋巴瘤病例中参与了高钙血症的产生——然而，因果关系的证明必须等待PTHrP组织释放导致循环激素水平升高的证据。
