Ito M, Nakashima M, Alipov G K, Matsuzaki S, Ohtsuru A, Yano H, Yamashita S, Sekine I
Department of Pathology, Atomic Disease Institute, Nagasaki University School of Medicine, Japan.
J Gastroenterol. 1997 Jun;32(3):396-400. doi: 10.1007/BF02934499.
Parathyroid hormone-related peptide (PTHrP) is involved in cell proliferation in both neoplastic and non-neoplastic tissues. We describe an autopsy case of gastric cancer in a patient who showed serum hypercalcemia and overexpression of PTHrP and PTH/PTHrP receptor in the metastatic tumor cells. The primary gastric tumor was poorly differentiated adenocarcinoma, and multiple metastases were present in the bone, multiple visceral organs, peritoneum, and lymph nodes. PTHrP and its mRNA were detected only in the metastatic tumor cells, but not in primary gastric tumor. PTH/PTHrP receptor was also demonstrated immunohistologically in metastatic tumor cells. This case suggests that the expression of PTHrP is related to tumor progression and the poor prognosis in tumors associated with humoral hypercalcemia.
甲状旁腺激素相关肽（PTHrP）参与肿瘤组织和非肿瘤组织中的细胞增殖。我们描述了一例胃癌尸检病例，该患者血清高钙血症，转移瘤细胞中PTHrP和PTH/PTHrP受体过表达。原发性胃肿瘤为低分化腺癌，骨、多个内脏器官、腹膜和淋巴结出现多处转移。仅在转移瘤细胞中检测到PTHrP及其mRNA，而原发性胃肿瘤中未检测到。转移瘤细胞中也通过免疫组织化学证实了PTH/PTHrP受体的存在。该病例表明，PTHrP的表达与肿瘤进展以及与体液性高钙血症相关肿瘤的不良预后有关。
