Chachaj Angelika, Drozdz Katarzyna, Szuba Andrzej
Department of Internal Medicine, Wroclaw Medical University, 4 Pasteur St., 50-367 Wroclaw, Poland.
Postepy Biochem. 2008;54(3):301-7.
Atherosclerosis represents dynamic process with periodic tendency to reverse. Although animal experiments and human studies have provided considerable evidence of atherosclerosis regression, our understanding of this phenomenon remains still incomplete. Atherosclerosis regression depends on removal of cholesterol deposits from atherosclerotic plague in the process of reverse cholesterol transport and possibly other mechanisms including migration of macrophages and foam cells, inhibition of inflammation and endothelial regeneration. Our paper reviews available data on the process of atherosclerosis regression with special attention to the reverse cholesterol transport.
动脉粥样硬化是一个具有周期性逆转倾向的动态过程。尽管动物实验和人体研究已经提供了大量动脉粥样硬化逆转的证据，但我们对这一现象的理解仍然不完整。动脉粥样硬化的逆转取决于在逆向胆固醇转运过程中从动脉粥样硬化斑块中清除胆固醇沉积物，以及可能的其他机制，包括巨噬细胞和泡沫细胞的迁移、炎症抑制和内皮再生。我们的论文回顾了有关动脉粥样硬化逆转过程的现有数据，并特别关注逆向胆固醇转运。
