Gałecka Elzbieta, Mrowicka Małgorzata, Malinowska Katarzyna, Gałecki Piotr
Uniwersytet Medyczny w Łodzi, Zaktad Chemii i Biochemii Klinicznej.
Pol Merkur Lekarski. 2008 Sep;25(147):269-72.
Free radicals are substantial elements that take part in proper function of metabolic pathways of human cells and tissues in hydrophobic as well as in hydrophilic environment. Nevertheless overproduction of above molecules causes oxidative stress, a process which is very harmful for lipids, proteins, and others molecules what reduces their normal function. To protect against adverse effects of free radicals and theirs derivatives to human body there is a group of antioxidants divided into enzymatic and non-enzymatic substances. Enzymatic antioxidants are represented mainly by enzymes such as: copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR). Glutathione (GSH), thioredoxin (Trx), vitamins, melatonin, polyphenols, trace elements, albumin, and others function as non-enzymatic free radicals scavengers. This work in a brief way describes properties of chosen representants of non-enzymatic antioxidant system.
自由基是在疏水和亲水环境中参与人体细胞和组织代谢途径正常功能的重要元素。然而，上述分子的过量产生会导致氧化应激，这一过程对脂质、蛋白质和其他分子非常有害，会降低它们的正常功能。为了防止自由基及其衍生物对人体产生不良影响，有一组抗氧化剂，分为酶促和非酶促物质。酶促抗氧化剂主要由铜锌超氧化物歧化酶（CuZnSOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）和谷胱甘肽还原酶（GR）等酶代表。谷胱甘肽（GSH）、硫氧还蛋白（Trx）、维生素、褪黑素、多酚、微量元素、白蛋白等作为非酶促自由基清除剂发挥作用。这项工作简要描述了非酶促抗氧化系统所选代表的特性。
