Agner T
Department of Dermatology, Rigshospitalet, Copenhagen, Denmark.
Br J Dermatol. 1991 Aug;125(2):140-6. doi: 10.1111/j.1365-2133.1991.tb06061.x.
Basic physiological characteristics were examined in the uninvolved skin of 39 patients with hand eczema and in 39 healthy controls. Susceptibility to sodium lauryl sulphate (SLS)-induced irritant dermatitis was evaluated by the application of a single 24-h SLS patch test to the upper arm. Transepidermal water loss (TEWL) was measured by an evaporimeter, skin thickness by ultrasound A-scan, blood flow by laser-Doppler flowmetry and skin colour by a chroma meter using the Lab* system of the Commission Internationale de l'Eclairage (CIE). No difference in basal TEWL values was found between patients and controls. A decreased skin thickness was found in those with hand eczema as compared to the controls. The hand eczema patients had significantly increased L* and decreased b*-values compared to controls, indicating a more 'fair' skin. Susceptibility to SLS was increased only in patients with acute eczema, indicating that the presence of an active eczema increases the reactivity to irritants of distant uninvolved skin.
对39例手部湿疹患者未受累皮肤及39名健康对照者的基本生理特征进行了检查。通过在上臂进行单次24小时的月桂醇硫酸酯钠（SLS）斑贴试验，评估对SLS诱导的刺激性皮炎的易感性。经皮水分流失（TEWL）用蒸发仪测量，皮肤厚度用超声A扫描测量，血流用激光多普勒血流仪测量，皮肤颜色用色度计根据国际照明委员会（CIE）的Lab系统测量。患者和对照者之间的基础TEWL值没有差异。与对照组相比，手部湿疹患者的皮肤厚度降低。与对照组相比，手部湿疹患者的L值显著升高，b*值降低，表明皮肤更“白皙”。仅急性湿疹患者对SLS的易感性增加，这表明活动性湿疹的存在会增加远处未受累皮肤对刺激物的反应性。
