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[胶质瘤患者术后癫痫的诱发因素]

[Predisposing factors for postoperative epilepsy in patients with gliomas].

作者信息

Qiu Bing-hui, Gong Fang-he, Fang Lu-xiong, Qi Song-tao

机构信息

Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2008 Dec;28(12):2233-4.

Abstract

OBJECTIVE

To explore the predisposing factors for postoperative epilepsy in patients with gliomas.

METHODS

A total of 258 glioma patients with complete clinical data receiving cranial surgeries were analyzed retrospectively. With gender, age, predominant symptoms, positive signs, history of preoperative epilepsy, time of epilepsy onset, tumor location, surgical approaches, cortical injury, arterial and venous injury, scope of tumor resection, postoperative edema, tumor pathology, tumor recurrence, number of operation, radiation therapy as the independent variables, the occurrence of postoperative epilepsy was analyzed as the dependent variable using logistic regression to identify the risk factors for postoperative epilepsy.

RESULTS

History of preoperative epilepsy, surgical approaches, postoperative edema, tumor pathology and tumor recurrence were identified as the risk factors for postoperative epilepsy in glioma patients.

CONCLUSIONS

Postoperative epilepsy severely affected the quality of life of glioma patients, and rigorous treatment targeting the risk factors may decrease the occurrence of postoperative epilepsy.

摘要

目的

探讨胶质瘤患者术后癫痫发作的易感因素。

方法

回顾性分析258例接受颅脑手术且临床资料完整的胶质瘤患者。以性别、年龄、主要症状、阳性体征、术前癫痫病史、癫痫发作时间、肿瘤位置、手术方式、皮质损伤、动静脉损伤、肿瘤切除范围、术后水肿、肿瘤病理、肿瘤复发、手术次数、放疗作为自变量,将术后癫痫发作情况作为因变量,采用logistic回归分析确定术后癫痫发作的危险因素。

结果

术前癫痫病史、手术方式、术后水肿、肿瘤病理及肿瘤复发被确定为胶质瘤患者术后癫痫发作的危险因素。

结论

术后癫痫严重影响胶质瘤患者的生活质量,针对危险因素进行严格治疗可能会降低术后癫痫的发生率。

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