Gousias K, Markou M, Voulgaris S, Goussia A, Voulgari P, Bai M, Polyzoidis K, Kyritsis A, Alamanos Y
Department of Neurosurgery, University of Ioannina, Ioannina, Greece.
Neuroepidemiology. 2009;33(2):89-95. doi: 10.1159/000222090. Epub 2009 May 30.
To investigate the epidemiologic and clinical characteristics (age, sex, tumor location, socioeconomic status) and potential predisposing factors (alcohol, tobacco, mobile phone use, severe head trauma) of cerebral gliomas in a defined area of Northwest Greece.
The prospective study was conducted in patients with gliomas referred to all 7 hospitals of a study area with a population of 488,435 inhabitants, from June 1, 2005, to May 31, 2007. Incidence rates (IR) were calculated as new cases diagnosed among residents of the study area during the study period per 100,000 inhabitants. A case-control study was carried out in order to study the possible association of the risk of glioma with smoking, alcohol, use of mobile phone, and severe cranial trauma.
A total of 56 glioma incident cases were identified with IRs of glioma and glioblastoma (GBM) at 5.73/10(5)/year and 3.69/10(5)/year, respectively. A male to female ratio of 1.25 was obtained in the GBM group. IRs of glioma and GBM for both males and females were higher in the age group 60-79. The most frequent anatomic location was the frontal lobe. 46.5% of the patients originated from the low, 25% from the middle and 28.5% from the high socioeconomic class. There was no significant association between glioma and alcohol consumption, smoking and mobile phone use. A trend for a positive association between the risk of glioma and a history of severe cranial trauma was observed, but this association was not statistically significant.
The estimated IR of glioma and GBM in this study was higher compared with data from other studies carried out on European, Asian and US populations. Further studies may be needed to assess the possible association of genetic, environmental and lifestyle factors with the high occurrence of gliomas observed in this study.
调查希腊西北部某特定地区脑胶质瘤的流行病学和临床特征（年龄、性别、肿瘤位置、社会经济状况）以及潜在的诱发因素（酒精、烟草、手机使用、严重头部创伤）。
这项前瞻性研究于2005年6月1日至2007年5月31日在研究区域内的7家医院对胶质瘤患者进行，该研究区域人口为488,435人。发病率（IR）计算为研究期间研究区域居民中每10万居民确诊的新病例数。开展了一项病例对照研究，以研究胶质瘤风险与吸烟、饮酒、手机使用和严重颅脑创伤之间的可能关联。
共确定了56例胶质瘤发病病例，胶质瘤和胶质母细胞瘤（GBM）的发病率分别为5.73/10⁵/年和3.69/10⁵/年。GBM组的男女比例为1.25。60 - 79岁年龄组中，男性和女性的胶质瘤和GBM发病率均较高。最常见的解剖位置是额叶。46.5%的患者来自低社会经济阶层，25%来自中等社会经济阶层，28.5%来自高社会经济阶层。胶质瘤与饮酒、吸烟和手机使用之间无显著关联。观察到胶质瘤风险与严重颅脑创伤史之间存在正相关趋势，但这种关联无统计学意义。
与对欧洲、亚洲和美国人群进行的其他研究数据相比，本研究中估计的胶质瘤和GBM发病率更高。可能需要进一步研究来评估遗传、环境和生活方式因素与本研究中观察到的胶质瘤高发病率之间的可能关联。
