Sharar S R, Ready L B, Ross B K, Chadwick H S, Sudy D J
Department of Anesthesiology, University of Washington School of Medicine, Seattle 98195.
Reg Anesth. 1991 Jul-Aug;16(4):232-5.
To assess the relative efficacy and incidence of side effects of a single injection versus a continuous infusion of epidural morphine sulfate (MS) in the postcesarean population, the authors report a prospective, randomized, double-blind study. Thirty-one patients received either a 5-mg MS bolus and subsequent saline infusion (n = 13) or a 2.6-mg MS bolus and subsequent MS infusion at 0.1 mg/hour (n = 18), such that after 24 hours both groups had received a total MS dose of 5 mg. No statistically significant differences were found between the two groups in overall satisfaction with analgesia, verbal pain scores, level of activity, need for supplemental opioids, or incidence of sedation during the 24-hour study period. The authors conclude that in this population, continuous epidural morphine infusion offers no obvious advantage over single morphine bolus therapy. However, the theoretical merits of continuous opioid infusion therapy are discussed.
为评估剖宫产术后单次注射与持续输注硫酸吗啡硬膜外给药的相对疗效及副作用发生率，作者进行了一项前瞻性、随机、双盲研究。31例患者分别接受5mg吗啡推注及随后的生理盐水输注（n = 13）或2.6mg吗啡推注及随后0.1mg/h的吗啡输注（n = 18），以使两组在24小时后均接受总量为5mg的吗啡。在24小时研究期间，两组在镇痛总体满意度、言语疼痛评分、活动水平、补充阿片类药物的需求或镇静发生率方面均未发现统计学显著差异。作者得出结论，在该人群中，持续硬膜外吗啡输注相较于单次吗啡推注疗法并无明显优势。然而，文中讨论了持续阿片类药物输注疗法的理论优点。
