Altintaş Engin, Uçbilek Enver, Sezgin Orhan, Sayici Yasin
Department of Gastroenterology, Mersin University, School of Medicine, Mersin, Turkey.
Turk J Gastroenterol. 2008 Sep;19(3):174-9.
BACKGROUND/AIMS: Successful colonoscopy depends on the insertion of the instrument to the cecum, a detailed examination, and minimal discomfort to the patient during the procedure. The aim of this study was to determine the effects of alverine citrate plus simethicone on the cecal intubation time, colonic spasm and bowel cleanliness.
A prospective, randomized, controlled trial in a consecutive series of patients was conducted to compare alverine citrate as an antispasmodic agent for relaxation of spasm with elective colonoscopy. The drug used consisted of 60 mg alverine citrate plus 300 mg simethicone. Sodium phosphate soda and enema were recommended for bowel cleansing. During colonoscopy, spasticity, difficulty of the procedure, pain, and cleanliness of the colon were scored between 0-4. The time required to reach the cecum was recorded as minutes.
Of 165 total patients, 83 and 82 patients were randomized as the drug group (mean age: 51.85+/-13.47 years) and control group (mean age: 51.68+/-16.28 years), respectively. There was a statistically significant difference between the groups in the mean time to reach the cecum in favor of the drug group (7.48+/-3.45 minutes vs. 6.20+/-3.24 minutes; p=0.02). The time to reach the cecum prolonged with an increase in pain score and difficulty score (p=0.0001 and p=0.001, respectively).
Alverine citrate plus simethicone reduced the intubation time significantly by 19%, from 7.48 minutes to 6.20 minutes.
背景/目的：成功的结肠镜检查取决于将器械插入盲肠、进行详细检查以及在操作过程中使患者不适最小化。本研究的目的是确定枸橼酸阿尔维林加西甲硅油对盲肠插管时间、结肠痉挛和肠道清洁度的影响。
对一系列连续患者进行前瞻性、随机、对照试验，以比较枸橼酸阿尔维林作为一种解痉剂在选择性结肠镜检查中缓解痉挛的效果。使用的药物为60毫克枸橼酸阿尔维林加300毫克西甲硅油。推荐使用磷酸钠苏打和灌肠剂进行肠道清洁。在结肠镜检查期间，对痉挛、操作难度、疼痛和结肠清洁度在0至4分之间进行评分。到达盲肠所需的时间记录为分钟。
在165例患者中，分别有83例和82例患者被随机分为药物组（平均年龄：51.85±13.47岁）和对照组（平均年龄：51.68±16.28岁）。两组在到达盲肠的平均时间上存在统计学显著差异，有利于药物组（7.48±3.45分钟对6.20±3.24分钟；p = 0.02）。到达盲肠的时间随着疼痛评分和难度评分的增加而延长（分别为p = 0.0001和p = 0.001）。
枸橼酸阿尔维林加西甲硅油显著缩短了插管时间19%，从7.48分钟降至6.20分钟。
