Rao Y, Wang Y L, Li H, Zhang W, Liu J
Department ofAnesthesiology, Zhongnan Hospital, Wuhan University, Hubei, PR China.
Anaesth Intensive Care. 2008 Nov;36(6):830-4. doi: 10.1177/0310057X0803600612.
This study was designed to evaluate the effects of pregnancy on the solubility of halogenated volatile anaesthetics in rat blood and tissues. Tissue samples from 10 pregnant and 10 non-pregnant adult female Sprague Dawley rats, including the heart, liver, kidney and brain, were obtained and made into respective homogenates. Blood/gas and tissue/gas partition coefficients for halothane, sevoflurane and isoflurane were determined by the method of two-stage headspace equilibration by gas chromatography with each of the homogenates. Values were analysed by t-test or one-way analysis of variance. The solubility within blood and brain for halothane in the pregnant group (2.90 +/- 0.44, 5.55 +/- 0.73) was significantly lower than that of the non-pregnant group (3.42 +/- 023, 6.33 +/- 0.64; P < 0.05). However, there were no significant differences between the two groups for liver, kidney or heart solubility. For sevoflurane and isoflurane, there were no significant differences in solubility between the two groups. In conclusion, pregnancy decreased the solubility of halothane within the blood and brain, whereas the solubility of halothane in other tissues including the liver, kidney and heart showed no significant alteration. Pregnancy did not affect the solubility ofsevoflurane or isoflurane within blood or the other tissues studied.
本研究旨在评估妊娠对卤代挥发性麻醉药在大鼠血液和组织中溶解度的影响。从10只怀孕和10只未怀孕的成年雌性Sprague Dawley大鼠获取包括心脏、肝脏、肾脏和大脑在内的组织样本，并制成各自的匀浆。采用气相色谱法通过两阶段顶空平衡法测定氟烷、七氟烷和异氟烷在各匀浆中的血/气和组织/气分配系数。数值通过t检验或单因素方差分析进行分析。怀孕组中氟烷在血液和大脑中的溶解度（2.90±0.44，5.55±0.73）显著低于未怀孕组（3.42±0.23，6.33±0.64；P<0.05）。然而，两组在肝脏、肾脏或心脏溶解度方面无显著差异。对于七氟烷和异氟烷，两组之间的溶解度无显著差异。总之，妊娠降低了氟烷在血液和大脑中的溶解度，而氟烷在包括肝脏、肾脏和心脏在内的其他组织中的溶解度无显著变化。妊娠不影响七氟烷或异氟烷在血液或其他研究组织中的溶解度。
