肥胖女性血清脂联素与子宫内膜癌及非典型子宫内膜增生的关系
Serum adiponectin in relation to endometrial cancer and endometrial hyperplasia with atypia in obese women.
作者信息
Rzepka-Górska I, Bedner R, Cymbaluk-Płoska A, Chudecka-Głaz A
机构信息
Department of Gynecological Surgery and Oncology of Adults and Adolescents, Pomeranian Medical University of Szczecin, Poland.
出版信息
Eur J Gynaecol Oncol. 2008;29(6):594-7.
OBJECTIVES
The aim of this work was to compare concentrations of adiponectin in the serum of obese women with endometrial cancer, endometrial hyperplasia with atypia, and normal endometrium.
METHODS
We enrolled 105 obese women treated at the Department of Gynecological Surgery and Oncology of Adults and Adolescents. The patients were allocated to groups depending on the histological diagnosis (R - endometrial cancer, P - polyps, K - normal endometrium). We subdivided group R depending on the stage and grade of cancer.
RESULTS
Significantly lower concentrations of adiponectin were found in patients with endometrial cancer (mean 15.28 microg/ml) as compared with polyps (29.94 microg/ml, p < 0.001) or normal endometrium (22.7 microg/ml, p < 0.05). Stage of cancer had no significant effect on the adiponectin level. When cancer grade was compared, lower levels of adiponectin were observed in patients with G3 (12.86 microg/ml) than G1 (19.04 microg/ml, p < 0.05).
CONCLUSION
Reduced levels of adiponectin may represent an independent risk factor for endometrial cancer.
目的
本研究旨在比较肥胖的子宫内膜癌女性、非典型子宫内膜增生女性及正常子宫内膜女性血清中脂联素的浓度。
方法
我们招募了105名在成人及青少年妇科手术与肿瘤学系接受治疗的肥胖女性。根据组织学诊断将患者分组（R - 子宫内膜癌，P - 息肉，K - 正常子宫内膜）。我们根据癌症的分期和分级对R组进行了细分。
结果
与息肉组（29.94微克/毫升，p < 0.001）或正常子宫内膜组（22.7微克/毫升，p < 0.05）相比，子宫内膜癌患者的脂联素浓度显著降低（平均15.28微克/毫升）。癌症分期对脂联素水平无显著影响。比较癌症分级时，G3级患者（12.86微克/毫升）的脂联素水平低于G1级患者（19.04微克/毫升，p < 0.05）。
结论
脂联素水平降低可能是子宫内膜癌的一个独立危险因素。
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