Cymbaluk Aneta, Chudecka-Głaz Anita, Rzepka-Górska Izabella
Chair and Department of Gynecological Surgery and Oncology of Adults and Adolescents, Pomeranian Medical University, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
Eur J Obstet Gynecol Reprod Biol. 2008 Jan;136(1):74-7. doi: 10.1016/j.ejogrb.2006.08.012. Epub 2006 Sep 27.
Leptin levels in serum depending on Body Mass Index (BMI) in patients with endometrial hyperplasia and cancer.
Concentrations of leptin, a hormone secreted by white adipose tissue, correlate strongly with body mass. Leptin interacts with several other hormones, modifies the activities of some enzymes and proinflammatory cytokines, participates in hematopoiesis, thermogenesis, and angiogenesis, and is involved in the control of carbohydrate and lipid metabolism. This study was undertaken to determine whether serum concentrations of leptin in obese patients with endometrial hyperplasia and cancer deviate from values in patients with normal endometrium.
We enrolled 86 obese postmenopausal women, including 40 with endometrial cancer and hyperplasia and 46 with normal endometrium. Depending on BMI, three subgroups were formed: I<30; II = 30-40; III > 40. Leptin concentrations were measured with immunoenzymatic test kits from IBL. Statistical comparison was done with the chi square (chi(2)) test and Statistica software package.
Mean serum concentration of leptin in endometrial cancer and hyperplasia was 16737.1 pg/ml as opposed to 9048.7 pg/ml in patients without endometrial pathology (p<0.0001). Significantly, higher concentrations of leptin were noted in every BMI subgroup of patients with endometrial pathology in comparison to controls (p<0.005).
Leptin appears to participate in proliferative processes of the endometrium. Obesity is an important risk factor in endometrial cancer.
子宫内膜增生和癌症患者血清中瘦素水平与体重指数（BMI）的关系。
瘦素是一种由白色脂肪组织分泌的激素，其浓度与体重密切相关。瘦素与其他几种激素相互作用，改变某些酶和促炎细胞因子的活性，参与造血、产热和血管生成，并参与碳水化合物和脂质代谢的调控。本研究旨在确定肥胖的子宫内膜增生和癌症患者血清瘦素浓度是否与正常子宫内膜患者的值不同。
我们纳入了86名肥胖的绝经后妇女，其中40名患有子宫内膜癌和增生，46名子宫内膜正常。根据BMI形成三个亚组：I<30；II = 30 - 40；III > 40。使用IBL的免疫酶测试试剂盒测量瘦素浓度。采用卡方（chi(2)）检验和Statistica软件包进行统计比较。
子宫内膜癌和增生患者的血清瘦素平均浓度为16737.1 pg/ml，而无子宫内膜病变患者为9048.7 pg/ml（p<0.0001）。值得注意的是，与对照组相比，子宫内膜病变患者的每个BMI亚组中瘦素浓度均显著更高（p<0.005）。
瘦素似乎参与子宫内膜的增殖过程。肥胖是子宫内膜癌的一个重要危险因素。
