Meggiorini M L, Labi L, Vestri A R, Porfiri L M, Savelli S, De Felice C
Department of Gynecology, Perinatology and Child Health, "Sapienza", University of Rome, Rome, Italy.
Eur J Gynaecol Oncol. 2008;29(6):598-601.
To evaluate the effect of tamoxifen on mammographic density using a qualitative and a semiquantitative method.
Mammograms from 148 women treated for breast cancer before and after surgery were reviewed: 68 were administered tamoxifen; 80 did not receive tamoxifen. The mammograms were classified in one of the four BIRADS density categories by two radiologists blinded to the treatment and by a computer-assisted method after digitizing images.
At mammographic one-year-follow-up density was reduced in both groups and remained stable in the following years. A comparison of mammograms performed before surgery and after one year showed a statistically significant difference in density reduction between the tamoxifen and the non-tamoxifen-treated group. Good agreement was obtained between the qualitative and semiquantitative method.
Breast density reduction observed in women treated with tamoxifen may help in the detection of small tumors in dense breasts by means of reducing the masking effect of parenchyma.
采用定性和半定量方法评估他莫昔芬对乳腺X线密度的影响。
回顾了148例乳腺癌患者手术前后的乳腺X线片：68例服用他莫昔芬；80例未接受他莫昔芬治疗。由两位对治疗不知情的放射科医生以及在图像数字化后通过计算机辅助方法将乳腺X线片分类为四种BIRADS密度类别之一。
在乳腺X线片一年随访时，两组的密度均降低，且在随后几年保持稳定。手术前和一年后的乳腺X线片比较显示，他莫昔芬治疗组和未接受他莫昔芬治疗组在密度降低方面存在统计学显著差异。定性和半定量方法之间取得了良好的一致性。
服用他莫昔芬的女性中观察到的乳腺密度降低可能有助于通过减少实质的掩盖效应来检测致密乳腺中的小肿瘤。
