Baribeau Y, Eugene J, Nhu T T, Firestein S L, Liaw Y, Yow L, Hammer-Wilson M, Berns M W
Department of Surgery, University of California, Irvine 92717.
J Invest Surg. 1991;4(3):247-58. doi: 10.3109/08941939109141157.
Open laser endarterectomy produces a smooth arterial surface with welded distal end points. This report evaluates 308-nm excimer laser radiation for the laser endarterectomy operation. Arteriosclerotic New Zealand white rabbits (N = 15) were studied. A thoraco-abdominal exploration was performed, the aorta was isolated, heparin was administered, and multiple endarterectomies were performed in each rabbit. A line of laser craters was created at the proximal and distal ends of an atheroma. Laser radiation was used to connect the craters to form the proximal and distal end points. The atheromas were dissected from the aorta with laser light and the end points were fused. The aortas were removed for light and electron microscopy and the animals were sacrificed. Excimer radiation was delivered by a 600-microns fiber at 50 mJ/pulse, 120-ns pulses and either 15- or 20-Hz frequency. At 15 Hz excimer laser endarterectomies showed no perforations along the surface or at the end points. The surfaces were smooth but the end points were not welded in place. At 20 Hz, perforations were seen along 7/11 surfaces and at 5/11 end points. Excimer laser endarterectomy is best performed at 15 Hz. The end points, however, cannot be welded with excimer laser radiation.
开放式激光动脉内膜切除术可产生具有焊接远端端点的光滑动脉表面。本报告评估了用于激光动脉内膜切除术的308纳米准分子激光辐射。对15只患有动脉硬化的新西兰白兔进行了研究。进行了胸腹探查，分离出主动脉，给予肝素，并在每只兔子身上进行了多次动脉内膜切除术。在动脉粥样硬化斑块的近端和远端形成一排激光弹坑。使用激光辐射连接弹坑以形成近端和远端端点。用激光从主动脉中剥离动脉粥样硬化斑块并融合端点。取出主动脉进行光学显微镜和电子显微镜检查，并处死动物。准分子辐射通过一根600微米的光纤以50毫焦/脉冲、120纳秒脉冲和15或20赫兹的频率传递。在15赫兹时，准分子激光动脉内膜切除术在表面或端点未显示穿孔。表面光滑，但端点未焊接到位。在20赫兹时，在7/11的表面和5/11的端点可见穿孔。准分子激光动脉内膜切除术最好在15赫兹下进行。然而，端点不能用准分子激光辐射焊接。
