Eugene J, McColgan S J, Hammer-Wilson M, Moore-Jeffries E W, Berns M W
Lasers Surg Med. 1985;5(3):309-20. doi: 10.1002/lsm.1900050313.
We have studied laser radiation of arteriosclerotic cardiovascular disease to determine the best technique for evaluation. Rabbits with arteriosclerosis were treated by intraluminal laser angioplasty (N = 8), laser angioscopy (N = 2), and open laser endarterectomy (N = 5). All studies were performed with an argon ion laser delivering energy through a 400-microns quartz fiber. Power delivered was varied in order to determine the best value for this animal model. Following angioplasty, perforation was seen in three rabbits (in one case, it was due to mechanical trauma from the fiber optic), and early thrombosis occurred in two rabbits. Plaques were vaporized by angioscopy, but the depth of laser beam penetration or angle of incidence could not be controlled. Open laser endarterectomy gave consistently good results with removal of an arteriosclerotic plaque within the media. The optimum power was found to be 1.0-2.0 W. Endarterectomy required an energy density of 100-140 J/cm2. We conclude that open laser endarterectomy can be a standardized technique for the in vivo evaluation of laser radiation upon arteriosclerotic lesions.
我们研究了激光辐射对动脉硬化性心血管疾病的作用，以确定最佳评估技术。对患有动脉硬化的兔子进行了腔内激光血管成形术（N = 8）、激光血管镜检查（N = 2）和开放式激光动脉内膜切除术（N = 5）。所有研究均使用通过400微米石英纤维传输能量的氩离子激光进行。为确定该动物模型的最佳值，改变了传输的功率。血管成形术后，3只兔子出现穿孔（其中1例是由于光纤的机械损伤），2只兔子发生早期血栓形成。通过血管镜检查可使斑块汽化，但无法控制激光束的穿透深度或入射角。开放式激光动脉内膜切除术在去除中膜内的动脉硬化斑块方面始终取得良好效果。发现最佳功率为1.0 - 2.0瓦。动脉内膜切除术所需的能量密度为100 - 140 J/cm²。我们得出结论，开放式激光动脉内膜切除术可作为一种标准化技术，用于体内评估激光辐射对动脉硬化病变的影响。
