小型综述：3-碘甲腺原氨酸胺（T1AM）：甲状腺内分泌团队中的新成员？
Minireview: 3-Iodothyronamine (T1AM): a new player on the thyroid endocrine team?
作者信息
Scanlan Thomas S
机构信息
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239-3098, USA.
出版信息
Endocrinology. 2009 Mar;150(3):1108-11. doi: 10.1210/en.2008-1596. Epub 2008 Dec 30.
Abstract
3-Iodothyronamine (T(1)AM) is an endogenous compound with chemical features that are similar to thyroid hormone. T(1)AM has a carbon skeleton identical to that of T(4) and contains a single carbon-iodine bond. Theoretically, T(1)AM could be produced from T(4) by enzymatic decarboxylation and deiodination. Recent studies show that T(1)AM and higher iodinated thyronamines are subject to similar metabolic processing as iodothyronines such as T(4), suggesting a biological linkage between iodothyronines and iodothyronamines. In addition, single doses of T(1)AM administered to rodents induce a hypometabolic state that in certain ways resembles hibernation and is opposite to the effects of excess T(4). This review will discuss the latest developments on this recently discovered thyroid hormone derivative.
摘要
3-碘甲腺原氨酸（T(1)AM）是一种内源性化合物，其化学特性与甲状腺激素相似。T(1)AM具有与T(4)相同的碳骨架，并含有一个碳-碘键。理论上，T(1)AM可通过酶促脱羧和脱碘作用由T(4)产生。最近的研究表明，T(1)AM和高碘化甲状腺胺与T(4)等碘甲状腺原氨酸经历相似的代谢过程，这表明碘甲状腺原氨酸和碘甲状腺胺之间存在生物学联系。此外，给啮齿动物单次注射T(1)AM会诱导一种低代谢状态，这种状态在某些方面类似于冬眠，且与过量T(4)的作用相反。本综述将讨论这种最近发现的甲状腺激素衍生物的最新进展。
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