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本文引用的文献

1
Increases in kidney volume in autosomal dominant polycystic kidney disease can be detected within 6 months.常染色体显性遗传性多囊肾病患者的肾体积增大在6个月内即可被检测到。
Kidney Int. 2009 Jan;75(2):235-41. doi: 10.1038/ki.2008.558. Epub 2008 Oct 29.
2
Magnetic resonance nephrourography: current and developing techniques.
Radiol Clin North Am. 2008 Jan;46(1):11-24, v. doi: 10.1016/j.rcl.2008.01.001.
3
Computed tomography evaluation of autosomal dominant polycystic kidney disease progression: a progress report.计算机断层扫描评估常染色体显性多囊肾病进展：一份进展报告。
Clin J Am Soc Nephrol. 2006 Jul;1(4):754-60. doi: 10.2215/CJN.02251205. Epub 2006 Jun 14.
4
Volume progression in polycystic kidney disease.多囊肾病中的体积进展
N Engl J Med. 2006 May 18;354(20):2122-30. doi: 10.1056/NEJMoa054341.
5
Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney disease.磁共振测量肾血流量作为常染色体显性多囊肾病疾病严重程度的标志物。
Kidney Int. 2003 Dec;64(6):2214-21. doi: 10.1046/j.1523-1755.2003.00326.x.

改进用于探究常染色体显性多囊肾病囊肿生长机制的临床试验设计。

Improving clinical trial design for inquiries into the mechanisms of cyst growth in ADPKD.

作者信息

Chapman Arlene B

机构信息

Emory University School of Medicine, Atlanta, Georgia 30322, USA.

出版信息

Kidney Int. 2009 Jan;75(2):139-41. doi: 10.1038/ki.2008.596.

DOI:10.1038/ki.2008.596
PMID:19116643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2693222/
Abstract

Accurate and reliable estimates of kidney and cyst volume, the hallmark of disease progression in ADPKD are now available. These powerful and exciting tools make it possible to consider both short and long term randomized clinical trials in ADPKD at various stages of disease. Highlights of the work by Kistler and colleagues are now provided.

摘要

现在可以获得对肾脏和囊肿体积的准确可靠估计，这是常染色体显性多囊肾病（ADPKD）疾病进展的标志。这些强大且令人兴奋的工具使得在ADPKD疾病的各个阶段开展短期和长期随机临床试验成为可能。现将基斯勒及其同事的工作重点介绍如下。