衰老会损害受体T细胞在移植反应中的内在和外在因素。
Aging impairs recipient T cell intrinsic and extrinsic factors in response to transplantation.
作者信息
Shen Hua, Tesar Bethany M, Du Wei, Goldstein Daniel R
机构信息
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
出版信息
PLoS One. 2009;4(1):e4097. doi: 10.1371/journal.pone.0004097. Epub 2009 Jan 1.
BACKGROUND
As increasing numbers of older people are listed for solid organ transplantation, there is an urgent need to better understand how aging modifies alloimmune responses. Here, we investigated whether aging impairs the ability of donor dendritic cells or recipient immunity to prime alloimmune responses to organ transplantation.
PRINCIPAL FINDINGS
Using murine experimental models, we found that aging impaired the host environment to expand and activate antigen specific CD8(+) T cells. Additionally, aging impaired the ability of polyclonal T cells to induce acute allograft rejection. However, the alloimmune priming capability of donor dendritic cells was preserved with aging.
CONCLUSION
Aging impairs recipient responses, both T cell intrinsic and extrinsic, in response to organ transplantation.
背景
随着越来越多的老年人被列入实体器官移植名单，迫切需要更好地了解衰老如何改变同种免疫反应。在此，我们研究了衰老是否会损害供体树突状细胞引发器官移植同种免疫反应的能力或受体免疫。
主要发现
使用小鼠实验模型，我们发现衰老损害了宿主环境中抗原特异性CD8(+) T细胞的扩增和激活能力。此外，衰老损害了多克隆T细胞诱导急性移植排斥反应的能力。然而，供体树突状细胞的同种免疫启动能力在衰老过程中得以保留。
结论
衰老会损害受体对器官移植的反应，包括T细胞内在和外在的反应。
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