紫外线诱导可能参与SOS修复的LexA非依赖性蛋白质。
UV induction of LexA independent proteins which could be involved in SOS repair.
作者信息
Lesca C, Petit C, Defais M
机构信息
Laboratoire de Pharmacologie et de Toxicologie Fondamentales, CNRS 205, Toulouse, France.
出版信息
Biochimie. 1991 Apr;73(4):407-9. doi: 10.1016/0300-9084(91)90107-c.
The SOS response is induced in E coli following treatments that interfere with DNA replication. The response is under the control of the recA and the lexA genes. Strains defective in LexA repressor constitutively express SOS proteins. However, SOS repair does not reach its maximum level in these strains. Instead, an activation of RecA protein and de novo protein synthesis are required for full repair. We have analyzed by 2-dimensional gel electrophoresis the induction of proteins after UV irradiation of lexA(Def) bacteria. Proteins which might participate in SOS repair are induced under these conditions.
在大肠杆菌中，干扰DNA复制的处理会诱导SOS反应。该反应受recA和lexA基因的控制。LexA阻遏物有缺陷的菌株组成型表达SOS蛋白。然而，这些菌株中的SOS修复并未达到其最大水平。相反，RecA蛋白的激活和从头蛋白质合成是完全修复所必需的。我们通过二维凝胶电泳分析了lexA（Def）细菌紫外线照射后蛋白质的诱导情况。在这些条件下，可能参与SOS修复的蛋白质被诱导。
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