Türkmen Nursel, Eren Bülent, Fedakar Recep, Akgöz Semra
Uludağ University Medical Faculty, Forensic Medicine Department, Turkey.
J Korean Med Sci. 2008 Dec;23(6):1020-6. doi: 10.3346/jkms.2008.23.6.1020. Epub 2008 Dec 24.
Hemosiderin deposition is not often recognized on routine examination with hematoxylin and eosin staining; however, iron stains may be helpful in the evaluation of hemosiderin deposition in infant autopsies. This report describes the data obtained from autopsy of 86 infants and children whose deaths were investigated at the Forensic Medicine Council Bursa Morgue Department from January 2000 to January 2003. A histochemical technique was used to identify hemosiderin in lung, liver and spleen specimens, which was correlated with other descriptive variables such as the reported cause of death, postmortem interval, trauma history, gender, and age. There was a weakly positive but significant correlation between lung and liver hemosiderin scores (Spearman's rank correlation coefficient, rho=0.348, p=0.001); i.e., given an increase in lung hemosiderin scores, an increase in liver hemosiderin scores was also observed. Similarly, a marked positive correlation between spleen and liver hemosiderin scores (Spearman's rank correlation coefficient, rho=0.335, p=0.002) was observed. The probability of spleen hemosiderin-positive cases belonging to the age group under 6 months was found to be 4.3 times greater than those who were hemosiderin-negative (95% confidence interval, 1.6-11.8). After the major differential diagnoses were ruled out, this study demonstrated, that depending on the statistically assessed morphometric grounds, the presence of hemosiderin deposits in the liver and spleen were significantly higher in the age group under 6 months.
含铁血黄素沉积在苏木精-伊红染色的常规检查中并不常被识别；然而，铁染色可能有助于评估婴儿尸检中的含铁血黄素沉积情况。本报告描述了2000年1月至2003年1月在布尔萨法医委员会停尸房部门对86例婴儿和儿童进行尸检所获得的数据。采用组织化学技术鉴定肺、肝和脾标本中的含铁血黄素，并将其与其他描述性变量相关联，如报告的死因、死后间隔、创伤史、性别和年龄。肺和肝含铁血黄素评分之间存在微弱但显著的正相关（Spearman等级相关系数，rho = 0.348，p = 0.001）；也就是说，随着肺含铁血黄素评分的增加，肝含铁血黄素评分也会增加。同样，观察到脾和肝含铁血黄素评分之间存在显著正相关（Spearman等级相关系数，rho = 0.335，p = 0.002）。发现6个月以下年龄组的脾含铁血黄素阳性病例的概率比含铁血黄素阴性病例高4.3倍（95%置信区间，1.6 - 11.8）。在排除主要鉴别诊断后，本研究表明，根据统计学评估的形态学依据，6个月以下年龄组肝和脾中含铁血黄素沉积的发生率显著更高。
