Kuong D D, Dovgiĭ A I, Adrianov N V, Varenitsa A I, Archakov A I
Biokhimiia. 1991 Apr;56(4):707-13.
It was found that rat liver cytochrome P-450 is induced by the Vietnamese ginseng triterpensaponines mixture (TSM) as well as by K5VN Panaxozides-11 (VP-11) purified from this mixture. Addition of TSM and VP-11 accelerates benz(alpha)pyrene and aminopyrine hydroxylation and increases the content of cytochrome P-450 isoforms with Mr of 57 kDa and 54 kDa in rat liver microsomes. Since VP-11 accounts for about 50% of TSM, the results obtained suggest that the microsomal monooxygenase system induction is caused by this triterpensaponine. Induction by TSM and VP-11 was compared to that by phenobarbital (PB) and 3-methylcholanthrene (MC). It was shown that according to their inductive action TSM and VP-11 belong neither to the PB- nor to the MC-type. Cytochrome P-450 induction may play an important role in the triterpensaponine action on the organism, because this enzyme participates in the metabolism of such endogenous compounds as prostaglandins, steroid hormones, cholesterol, etc.
研究发现，越南人参三萜皂苷混合物（TSM）以及从该混合物中纯化得到的K5VN人参氧化物-11（VP-11）可诱导大鼠肝脏细胞色素P-450。添加TSM和VP-11可加速苯并（α）芘和氨基比林的羟基化，并增加大鼠肝脏微粒体中分子量为57 kDa和54 kDa的细胞色素P-450同工型的含量。由于VP-11约占TSM的50%，所得结果表明微粒体单加氧酶系统的诱导是由这种三萜皂苷引起的。将TSM和VP-11的诱导作用与苯巴比妥（PB）和3-甲基胆蒽（MC）的诱导作用进行了比较。结果表明，根据其诱导作用，TSM和VP-11既不属于PB型也不属于MC型。细胞色素P-450的诱导可能在三萜皂苷对机体的作用中起重要作用，因为该酶参与前列腺素、甾体激素、胆固醇等内源性化合物的代谢。
