芹菜素对丝裂霉素C诱导的小鼠骨髓细胞遗传毒性损伤的抗遗传毒性作用。
Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells.
作者信息
Siddique Yasir Hasan, Afzal Mohammad
机构信息
Human Genetics and Toxicology Lab, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P. 202 002, India.
出版信息
Food Chem Toxicol. 2009 Mar;47(3):536-9. doi: 10.1016/j.fct.2008.12.006. Epub 2008 Dec 16.
The antigenotoxic effect of apigenin was studied against the genotoxic damage induced by mitomycin C on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Apigenin was studied at three different doses i.e. 10, 20 and 40 mg/kg b.w. and was found to be non-genotoxic at all the above three doses. Mitomycin C at 2 mg/kg b.w. was given along with the 10, 20 and 40 mg/kg bw of apigenin. A significant decrease in SCEs and CAs was observed, suggesting a protective role of apigenin against the genotoxicity of mitomycin C on mice bone marrow cells.
以姐妹染色单体交换（SCEs）和染色体畸变（CAs）为参数，研究了芹菜素对丝裂霉素C诱导的小鼠骨髓细胞遗传毒性损伤的抗遗传毒性作用。研究了芹菜素的三种不同剂量，即10、20和40mg/kg体重，发现上述三种剂量的芹菜素均无遗传毒性。2mg/kg体重的丝裂霉素C与10、20和40mg/kg体重的芹菜素一起给药。观察到SCEs和CAs显著减少，表明芹菜素对丝裂霉素C对小鼠骨髓细胞的遗传毒性具有保护作用。
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