表棓儿茶素对受雌二醇处理的人淋巴细胞的抗突变作用。
Anticlastogenic effect of apigenin in human lymphocytes treated with ethinylestradiol.
机构信息
Human Genetics and Toxicology Lab, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, UP 202002, India.
出版信息
Fitoterapia. 2010 Sep;81(6):590-4. doi: 10.1016/j.fitote.2010.02.003. Epub 2010 Feb 20.
In the present study the antigenotoxic effect of apigenin was studied against a genotoxic dose of ethinylestradiol using the damage parameters of chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and cell cycle kinetics (CCK). Human peripheral blood lymphocytes were cultured and treated with 10 microM of ethinylestradiol along with doses of 5, 10, 15 and 20 microM of apigenin. A clear decrease in the genotoxic damage induced by ethinylestradiol was observed with increasing doses of apigenin, suggesting a protective role for apigenin during ethinylestradiol therapy.
在本研究中，使用染色体畸变（CAs）、姐妹染色单体交换（SCEs）和细胞周期动力学（CCK）的损伤参数，研究了芹菜素对乙基雌二醇遗传毒性剂量的抗原毒性作用。用人外周血淋巴细胞进行培养，并分别用 5、10、15 和 20μM 的芹菜素处理 10μM 的乙基雌二醇。随着芹菜素剂量的增加，乙基雌二醇诱导的遗传毒性损伤明显减少，表明在乙基雌二醇治疗期间，芹菜素有保护作用。
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