在使用β受体阻滞剂的心绞痛患者中，硝酸盐可提高运动耐量。
Increased exercise tolerance with nitrates in beta-blockaded patients with angina.
作者信息
Baxter R H, Lennox I M
出版信息
Br Med J. 1977 Aug 27;2(6086):550-2. doi: 10.1136/bmj.2.6086.550.
Abstract
In 14 beta-blockaded anginal subjects, 10 of whom had poor left ventricular function, sublingual isosorbide dinitrate significantly increased maximal exercise capacity on a standardized multistage treadmill test. This was associated with changes in heart rate and blood pressure suggestive of a fall in left ventricular work. The effect of isosorbide lasts for at least two hours and when taken before exercise may be a useful addition to beta-blockade in patients with angina.
摘要
在14名接受β受体阻滞剂治疗的心绞痛患者中，其中10名左心室功能较差，在标准化多级跑步机测试中，舌下含服硝酸异山梨酯显著提高了最大运动能力。这与心率和血压的变化有关，提示左心室做功减少。硝酸异山梨酯的作用持续至少两小时，在运动前服用可能对心绞痛患者的β受体阻滞剂治疗有辅助作用。
相似文献
1
Increased exercise tolerance with nitrates in beta-blockaded patients with angina.
Br Med J. 1977 Aug 27;2(6086):550-2. doi: 10.1136/bmj.2.6086.550.
2
Effect of swallowed isosorbide dinitrate on blood pressure, heart rate and exercise capacity in patients with coronary artery disease.
Am J Med. 1977 Jan;62(1):39-46. doi: 10.1016/0002-9343(77)90347-3.
3
A new oral slow release form of isosorbide dinitrate. Effect on the hemodynamics and exercise capacity of patients with angina.
Chest. 1983 Dec;84(6):707-13. doi: 10.1378/chest.84.6.707.
4
[Ergometric study of the association of a beta-blocker and a nitrate derivative].
Nouv Presse Med. 1978 Sep 20;7(31):2727-31.
5
Clinical and circulatory effects of oral isosorbide dinitrate in patients with angina during exercise.
Acta Cardiol. 1975;30(4):293-312.
6
Antianginal effect of isosorbide dinitrate spray in patients with exercise-induced stable angina.
J Int Med Res. 1986;14(6):303-5. doi: 10.1177/030006058601400603.
7
Comparison of efficacy of nisoldipine, metoprolol, and isosorbide dinitrate in patients with stable exertional angina: a randomized, cross-over, placebo-controlled study.
Int J Cardiol. 1995 Feb;48(2):131-7. doi: 10.1016/0167-5273(94)02228-b.
8
Isosorbide dinitrate in clinical practice.
Scand J Clin Lab Invest Suppl. 1984;173:85-91.
9
Effects of propranolol and isosorbide dinitrate on exercise performance and adrenergic acitivity in patients with angina pectoris.
Circulation. 1969 Feb;39(2):157-69. doi: 10.1161/01.cir.39.2.157.
10
Anti-anginal efficacy of a controlled-release formulation of isosorbide-5-mononitrate once daily in angina patients on chronic beta-blockade.
Acta Med Scand. 1988;223(3):219-25. doi: 10.1111/j.0954-6820.1988.tb15790.x.
引用本文的文献
1
Haemodynamic and clinical effects of isosorbide-dinitrate in patients with severe effort angina on beta-blocking treatment.
Eur J Clin Pharmacol. 1983;24(2):169-72. doi: 10.1007/BF00613812.
2
Does the sympathetic nervous system influence sinus arrhythmia in man? Evidence from combined autonomic blockade.
J Physiol. 1984 Nov;356:459-64. doi: 10.1113/jphysiol.1984.sp015476.
3
Efficacy of transdermal glyceryl trinitrate in the treatment of chronic stable angina pectoris.
Br Heart J. 1985 Jun;53(6):631-5. doi: 10.1136/hrt.53.6.631.
4
Combination of nitrates with other antianginal drugs.
Drugs. 1987;33 Suppl 4:43-8. doi: 10.2165/00003495-198700334-00009.
5
Mononitrates in combination with beta-blocker therapy in the treatment of severe angina pectoris.
Drugs. 1987;33 Suppl 4:122-4. doi: 10.2165/00003495-198700334-00022.
6
Long term efficacy of a controlled-release formulation of isosorbide 5-mononitrate (Imdur) in angina patients receiving beta-blockers.
Drugs. 1987;33 Suppl 4:111-7. doi: 10.2165/00003495-198700334-00020.
本文引用的文献
1
USE OF PROPRANOLOL IN ANGINA PECTORIS.
Br Med J. 1965 Aug 7;2(5457):337-9. doi: 10.1136/bmj.2.5457.337.
2
DOUBLE-BLIND TRIAL OF PROPRANOLOL (INDERAL) IN ANGINA PECTORIS.
Br Med J. 1965 Apr 3;1(5439):897-8. doi: 10.1136/bmj.1.5439.897.
3
Effect of ischemia and antianginal drugs on the distribution of radioactive microspheres in the canine left ventricle.
Circ Res. 1971 Feb;28(2):263-9. doi: 10.1161/01.res.28.2.263.
4
The effect of propranolol in the long-term treatment of angina pectoris.
Arch Intern Med. 1969 Nov;124(5):578-83.
5
Hemodynamic effects of nitroglycerin, propranolol, and their combination in coronary heart disease.
Circulation. 1969 May;39(5):623-32. doi: 10.1161/01.cir.39.5.623.
6
Propranolol combined with isosorbide dinitrate versus placebo in angina pectoris.
N Engl J Med. 1969 Apr 17;280(16):847-50. doi: 10.1056/NEJM196904172801601.
7
Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease.
Am Heart J. 1973 Apr;85(4):546-62. doi: 10.1016/0002-8703(73)90502-4.
8
Comparative hemodynamic effects of placebo and oral isosorbide dinitrate in patients with significant coronary artery disease.
Am Heart J. 1975 Jul;90(1):68-74. doi: 10.1016/0002-8703(75)90258-6.
9
Hemodynamic effects of isosorbide dinitrate vs nitroglycerin in patients with unstable angina.
Chest. 1976 Jan;69(1):15-22. doi: 10.1378/chest.69.1.15.
10
Reversibility of left ventricular asynergy by nitroglycerin in coronary artery disease.
Am Heart J. 1975 Oct;90(4):479-86. doi: 10.1016/0002-8703(75)90430-5.
Zotero 插件