Baxter R H, Lennox I M
Br Med J. 1977 Aug 27;2(6086):550-2. doi: 10.1136/bmj.2.6086.550.
In 14 beta-blockaded anginal subjects, 10 of whom had poor left ventricular function, sublingual isosorbide dinitrate significantly increased maximal exercise capacity on a standardized multistage treadmill test. This was associated with changes in heart rate and blood pressure suggestive of a fall in left ventricular work. The effect of isosorbide lasts for at least two hours and when taken before exercise may be a useful addition to beta-blockade in patients with angina.
在14名接受β受体阻滞剂治疗的心绞痛患者中，其中10名左心室功能较差，在标准化多级跑步机测试中，舌下含服硝酸异山梨酯显著提高了最大运动能力。这与心率和血压的变化有关，提示左心室做功减少。硝酸异山梨酯的作用持续至少两小时，在运动前服用可能对心绞痛患者的β受体阻滞剂治疗有辅助作用。
