Coker R, Koziell A, Oliver C, Smith S E
J Physiol. 1984 Nov;356:459-64. doi: 10.1113/jphysiol.1984.sp015476.
The influences of vagal and sympathetic efferent activity on sinus arrhythmia in man have been studied in healthy subjects by administration of hyoscine butylbromide and atenolol alone and combined using a microcomputer-linked electrocardiogram (e.c.g.) system. Sinus arrhythmia was quantitated as the S.D. of the R-R interval. Sinus arrhythmia was reduced by hyoscine butylbromide, in some subjects to near abolition, but this end-point was unchanged by pre-treatment with atenolol. Atenolol alone prolonged the mean R-R interval and increased sinus arrhythmia. It is suggested that sinus arrhythmia in man is mediated through vagal efferents alone but that atenolol increases the arrhythmia through a central vagotonic effect.
通过单独使用丁溴东莨菪碱和阿替洛尔以及联合使用这两种药物，并借助微机连接心电图（ECG）系统，在健康受试者中研究了迷走神经和交感神经传出活动对人体窦性心律失常的影响。将窦性心律失常定量为R-R间期的标准差。丁溴东莨菪碱可使窦性心律失常减轻，在某些受试者中几乎消失，但阿替洛尔预处理对此终点无影响。单独使用阿替洛尔可延长平均R-R间期并增加窦性心律失常。提示人体窦性心律失常仅通过迷走神经传出纤维介导，但阿替洛尔通过中枢迷走神经兴奋作用增加心律失常。
