Hui Benjamin Wei-Qiang, Chiba Shunsuke
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Org Lett. 2009 Feb 5;11(3):729-32. doi: 10.1021/ol802816k.
Alpha-azido carbonyl compounds bearing a 2-alkenylaryl moiety at the alpha-position are found to be promising precursors for synthesis of isoindole and isoquinoline derivatives via 1,3-dipolar cycloaddition of azides onto alkenes and 6pi-electrocyclization of N-H imine intermediates, respectively.
发现在α-位带有2-烯基芳基部分的α-叠氮羰基化合物是分别通过叠氮化物与烯烃的1,3-偶极环加成以及N-H亚胺中间体的6π-电环化反应来合成异吲哚和异喹啉衍生物的有前景的前体。
