通过丙炔酸酯-烯烃[2+2]环加成反应合成 1,3-取代的环丁烷。
Synthesis of 1,3-Substituted Cyclobutanes by Allenoate-Alkene [2 + 2] Cycloaddition.
机构信息
Indiana University , Department of Chemistry, 800 East Kirkwood Ave, Bloomington, Indiana 47405, United States.
出版信息
J Org Chem. 2016 Sep 2;81(17):8050-60. doi: 10.1021/acs.joc.6b01446. Epub 2016 Aug 25.
Abstract
A method for the [2 + 2] cycloaddition of terminal alkenes with allenoates is presented. This process allows for the rapid synthesis of 1,3-substituted cyclobutanes in high yield under simple and robust reaction conditions.
摘要
本文提出了一种末端烯烃与丙二烯酸酯的[2+2]环加成方法。该方法在简单、稳健的反应条件下，以高产率快速合成了 1,3-取代的环丁烷。
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