Badawy Radwa A B, Harvey Anthony S, Macdonell Richard A L
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia.
J Clin Neurosci. 2009 Mar;16(3):355-65. doi: 10.1016/j.jocn.2008.08.026. Epub 2009 Jan 4.
Epilepsy encompasses a diverse group of seizure disorders caused by a variety of structural, cellular and molecular alterations of the brain primarily affecting the cerebral cortex, leading to recurrent unprovoked epileptic seizures. In this two-part review we examine the mechanisms underlying normal neuronal function and those predisposing to recurrent epileptic seizures starting at the most basic cellular derangements (Part 1) and working up to the highly complex epileptic networks (Part 2). We attempt to show that multiple factors can modify the epileptic process and that different mechanisms underlie different types of epilepsy, and in most situations there is an interplay between multiple genetic and environmental factors.
癫痫包括由大脑各种结构、细胞和分子改变引起的多种发作性疾病，主要影响大脑皮层，导致反复出现的无诱因癫痫发作。在这篇分两部分的综述中，我们从最基本的细胞紊乱（第1部分）开始，直至高度复杂的癫痫网络（第2部分），研究正常神经元功能的潜在机制以及那些易引发反复癫痫发作的机制。我们试图表明，多种因素可改变癫痫过程，不同类型的癫痫有不同的潜在机制，并且在大多数情况下，多种遗传和环境因素之间存在相互作用。
