Gottlieb Jens
Hannover Medical School Dpt. Respiratory Medicine OE 6870 Carl Neuberg-Str. 1 30625 Hannover, Germany. gottlieb.jens @mh-hannover.de
Ther Adv Respir Dis. 2008 Aug;2(4):237-47. doi: 10.1177/1753465808093514.
Lung transplantation is a suitable treatment to improve the quality of life and the prognosis of patients with various end-stage pulmonary diseases. There is a shortage of organs and the number of patients on waiting list is exceeding the number of transplants per year approximately two-fold in most countries. Strategies to increase the donor pool are therefore crucial. The long-term prognosis after lung transplantation is not yet as good as for other transplantation procedures and special complications should be taken into account. Aside from infections chronic organ dysfunction is the main cause of death and the most important prognosis limiting factor. Other typical problems are rejection, bronchus complications, and primary transplant dysfunction. However, the results of large centers show promising improvements in recent years.
肺移植是改善各种终末期肺部疾病患者生活质量和预后的一种合适治疗方法。在大多数国家，器官短缺，等待名单上的患者数量每年超过移植数量约两倍。因此，增加供体库的策略至关重要。肺移植后的长期预后尚未像其他移植手术那样良好，应考虑特殊并发症。除感染外，慢性器官功能障碍是主要死亡原因和最重要的预后限制因素。其他典型问题是排斥反应、支气管并发症和原发性移植功能障碍。然而，近年来大型中心的结果显示出有希望的改善。
