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[肺供体短缺:格罗宁根学术医院的3年经验]

[Shortage of lung donors: 3-year experience in the Groningen Academic Hospital].

作者信息

de Jong I J, Geertsma A, Kranenburg J, Tenvergert E M, de Boer W J

机构信息

Afd. Chirurgie, Academisch Ziekenhuis, Groningen.

出版信息

Ned Tijdschr Geneeskd. 1995 May 27;139(21):1078-82.

PMID:7783801
Abstract

OBJECTIVE

To analyse the background of the shortage of donor lungs; to present the procedure of allocation of donor lungs in the Eurotransplant region and the selection of donor lungs in the lung transplantation programme Groningen.

DESIGN

Descriptive.

SETTING

Groningen University Hospital.

METHODS

From March 23, 1991 to December 31, 1993, the lungs of 279 multi-organ donors were offered to the lung transplantation programme of Groningen University Hospital. The assessment and selection criteria are presented.

RESULTS

Only 35 out of all donor lungs offered could be used for transplantation: 24 double and 11 single lung transplants. Medical contraindications (notably pulmonary injury and hypoxaemia) were present in 155 out of the 244 (64%) lung donors. Forty-five out of 244 (18%) lung donors were rejected for logistic reasons, predominantly too little time between offer and imposed start of the explantation or long travel time.

CONCLUSION

Lung donor shortage is the main factor limiting the expansion of lung transplantation programmes. Increase of the number of suitable donors can be achieved by improving donor recognition and donor management, and by improving preservation techniques allowing increased acceptable cold ischaemia periods.

摘要

目的

分析供肺短缺的背景;介绍欧洲移植组织区域内供肺的分配程序以及格罗宁根肺移植项目中供肺的选择标准。

设计

描述性研究。

地点

格罗宁根大学医院。

方法

1991年3月23日至1993年12月31日期间,279例多器官供者的肺被提供给格罗宁根大学医院的肺移植项目。介绍了评估和选择标准。

结果

所有提供的供肺中仅有35例可用于移植:24例双肺移植和11例单肺移植。244例肺供者中有155例(64%)存在医学禁忌证(尤其是肺损伤和低氧血症)。244例肺供者中有45例(18%)因后勤原因被拒绝,主要是供肺通知与强制开始肺切除之间时间过短或运输时间过长。

结论

肺供者短缺是限制肺移植项目扩大的主要因素。通过改善供者识别和供者管理,以及改进保存技术以延长可接受的冷缺血时间,可以增加合适供者的数量。

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