治疗和未治疗的高血压患者的毛细血管稀疏。
Capillary rarefaction in treated and untreated hypertensive subjects.
作者信息
Cheng Cynthia, Daskalakis Constantine, Falkner Bonita
机构信息
Department of Family and Community Medicine, Thomas Jefferson University Hospital, Curtis Bldg, Suite 401, 1015 Walnut Street, Philadelphia, PA 19107, USA. Cynthia.Cheng@ jefferson.edu
出版信息
Ther Adv Cardiovasc Dis. 2008 Apr;2(2):79-88. doi: 10.1177/1753944708089696.
Abstract
This study aimed to determine if capillary rarefaction is detectable and associated with endothelial dysfunction in persons with mild systolic blood pressure (SBP) elevation. Capillary density and endothelial function were quantified for 150 nondiabetic participants, grouped by blood pressure (BP) as normotensive, untreated high BP, and treated high BP. Structural capillary rarefaction measures were not different between the three groups. Functional capillary rarefaction measures were significantly lower in both high BP groups compared to normotensives, and correlated inversely with endothelial function. The study findings indicate that the hypertensive vascular pathologic process is already underway at modest levels of blood pressure elevation.
摘要
本研究旨在确定在轻度收缩压（SBP）升高的人群中，是否可检测到毛细血管稀疏并与内皮功能障碍相关。对150名非糖尿病参与者的毛细血管密度和内皮功能进行了量化，根据血压（BP）分为正常血压组、未经治疗的高血压组和已治疗的高血压组。三组之间的结构性毛细血管稀疏指标没有差异。与正常血压组相比，两个高血压组的功能性毛细血管稀疏指标均显著降低，且与内皮功能呈负相关。研究结果表明，在血压轻度升高时，高血压血管病理过程就已经开始。
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